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A disrupted NAD + /NADH balance may contribute to the development of many diseases, including cardiovascular and neurodegenerative disorders such as Alzheimer's and Parkinson's disease, metabolic disorders such as type 2 diabetes, and inflammatory skin conditions such as acne and psoriasis (135–137)

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Given the heterogeneity of conditions underlying NPP, there is remains a notable scarcity of therapeutics that directly target non-neuronal cells implicated in NPP mechanisms, with cannabinoid receptor agonists being one of the few exceptions